Abstracts

Journal of American College of Cardiology,

Vol. 21, No. 2, February 1993:318A

925-116

Grapeseed Oil, A Natural Agent Which Raises Serum HDL Levels.

David T. Nash, Stephen D. Nash, State University of New York Health Science Center at Syracuse, William D. Grant, Department of Family Medicine, State University of New York Health Science Center at Syracuse, Syracuse, New York.

Grapeseed Oil (GSO) has been produced in Europe for hundreds of years as an edible oil, a byproduct of wine production.  GSO contains 75% linoleic acid, 15% oleic acid, 6% palmitic acid, 3% stearic acid, and 1% linolenic acid.  We studied the effect of GSO on HDL levels in a sample of 56 men and women all of whom had an initial HDL reading of <40mg% (fasting blood samples.)  All subjects had been on a lipid modified diet for more than three months prior to enrollment and gave informed consent to participate.  Subjects were instructed to use up to 45 ml of GSO in their daily diet a a substitute for their usual oil.  Fasting blood tests were performed at baseline and after three weeks' use of GSO.  No significant changes in this time period were noted for subjects' total cholesterol, triglycerides, or weight measurments.  However, statistically significant changes were noted for levels of High Density Lipoprotien cholesterol (HDL), an increase in mean values from 31.6mg% to 35.6mg% [t=5.79, p<.001, 95%CI 1.87 to 5.24], and for levels of Low Density Lipoprotein cholesterol (LDL), a decrease in mean values from 146mg% to 136mg% [t=2.71, p<.001, 95%CI -2.84 to 22.56].  The total cholesterol/HDL ratio was reduced 15.6%, and the LDL/HDL ratio was reduced by 15.3%.  The use of Grapeseed Oil in the daily diet appears to improve both HDL and LDL levels during a short term treatment period in weight stable subjects with initially low HDL levels.

 

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Arteriosclerosis: an official journal of the American Heart Association, Inc.

Vol. 1, No.1 (Jan.-Feb. 1981)

Vol. 10, No. 6 (Nov.-Dec. 1990).

 

Grapeseed Oil Increases High Density Lipoprotein Cholesterol Levels in Dyslipidemic Subjects with Initially Low Levels.

David T. Nash.  State University of New York Health Science Center, Syracuse, NY

 

Grapeseed oil (G) is a highly unsaturated natural food product extracted from grape seeds after the juice is pressed.  It contains 10% saturated fat, 66% linoleic acid and 22% oleic acid.  Thirty-three subjects (S) who had followed a low fat, low cholesterol diet for 3 months used 1 oz. of G in their daily diets for 4 weeks.  Fasting determinations of serum total cholesterol (C), triglycerides (T), high density lipoprotein cholesterol (H) and low density lipoprotein cholesterol (L) were performed at baseline (B), and at 2 and 4 weeks from B.  B levels of C 247 mg%, T 226 mg%, H 39.5 mg% and

L 167 mg% were compared to 4 week C 245 mg% (n.s.), T 187 mg% (reduced 17.2%; p<0.001), H 43.6 mg% (increased 10.4%; p<.01) and L 167 mg% (n.s.).  There were no significant changes in body weight in any of the S.  For the 19 S with baseline H less than 40 mg%, H baseline 32.8 mg% increased to 37.6 mg% (14.6%; p<.01).  For the 13 S who did not obtain a greater than 5% rise in H, only 4 had experienced a decrease in H greater than 5%. G, when used in the daily diet for 4 weeks, causes significant rises in H and reductions in T in dyslipidemic subjects.

 

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